Methicillin Resistant Staph

Is staph Methicillin resistant ?

        Currently, approximately 95% of strains are resistant to penicillin G, to aminopenicillines to carboxypenicillines and ureidopenicillines. Community strains are generally sensitive to penicillin M (Meticilline, oxacillin), which remains the antibiotic of choice. They are most often sensitive to macrolides, aminoglycosides, fluoroquinolones and synergistines. In recent years, we see the spread of community strains resistant to Meticilline but these strains remain a minority.

        Glycopeptides, rifampicin, fusidic acid, in descending order, the molecules that remain most active in these strains. These strains are more commonly known strains meti-R or MRSA (staphylococcus aureus resistant to Meticilline).

        Since 1997, strains with reduced susceptibility to glycopeptides have been described and they are more commonly called GISA (glycopeptide Intermediate staphylococcus aureus). The mechanism involved appears to be linked to the activation of the synthesis of bacterial cell wall in the absence of van genes responsible for glycopeptide resistance among enterococci.